We are in the midst of prominent
Glucosamine Hydrochloride exporters and suppliers, originated in India. We export glucosamine hydrochloride HCL which is strictly prepared from top quality raw material. Our glucosamine HCL is easily available at the most pocket friendly price. We have profound experience in dealing with different types of glucosamine hydrochloride HCL.
Glucosamine is one of the major building blocks utilized in the body's synthesis of the lubricants and shock absorbing mechanisms necessary to maintain and restore healthy joint performance. Glucosamine HCL supplementation enhances the body's ability to manufacture collagen and proteoglycans, which are essential for rebuilding joints, as well as synovial fluid which lubricate your joints.
Glucosamine is very beneficial in easing the pain of arthritis and this has been proven in numerous double-blind, placebo-controlled studies. In these studies, glucosamine has been shown to assist in the rehabilitation of cartilage and reduce the progression of osteoarthritis, and significantly lessen pain from arthritis. However, one glucosamine product can be very different from another.
Process : Glucosamine is not available from any primary food source but instead, is commercially prepared from chitin, which is the shell extract of shellfish such as lobster, crab and shrimp as well as animal connective tissues such as the marrow of chicken bones.
SOME SPECIAL FEATURES
- Glucosamine is useful for cartilage growth
- Glucosamine is used to treat and possibly slow the progression of osteoarthritis, the most common form of arthritis
- Glucosamine decreases pain and improves mobility. Besides, it is much less irritating to the gastrointestinal tract
- It helps support the building and maintenance of collagen between joints
- The unique formula contains additional herbal ingredients to help support joint mobility and help protect against the breakdown of joint cartilage and tissues
- High impact sports, muscle weakness, and repetitive stress injuries can cause joints to weaken; this formula helps ease joint movement and flexibility to help you enjoy everyday activities
Safety
Clinical studies of glucosamine have consistently reported that glucosamine appears safe. Since glucosamine is usually derived from shellfish, those allergic to shellfish may wish to avoid it. However, since glucosamine is derived from the shells of these animals while the allergen is within the flesh of the animals, it is probably safe even for those with shellfish allergy (Gray et al. 1994). Alternative sources using fungal fermentation of corn are available. Another concern has been that the extra glucosamine could contribute to diabetes by interfering with the normal regulation of the hexosamine biosynthesis pathway (Buse, 2006), but several investigations have found no evidence that this occurs (Scroggie et al., 2003). The U.S. National Institutes of Health is currently conducting a study of supplemental glucosamine in obese patients, since this population may be particularly sensitive to any effects of glucosamine on insulin resistance. [4]. Finally, in the United States, glucosamine is sold as a dietary supplement, so safety and formulation is solely the responsibility of the manufacturer.
Clinical Studies
There have been multiple clinical trials of glucosamine as a medical therapy for osteoarthritis, but results have been conflicting. The evidence both for and against glucosamine's efficacy has led to debate among physicians about whether to recommend glucosamine treatment to their patients (Manson and Rahman, 2004).
Multiple clinical trials in the 1980s and 1990s, all sponsored by the European patent-holder (Rottapharm), demonstrated a benefit for glucosamine. However, these studies were of poor quality due to shortcomings in their methods, including small size, short duration, poor analysis of drop-outs, and unclear procedures for blinding (Adams, 1999; McAlindon et al., 2000). Rotta then sponsored two large (at least 100 patients per group), three-year-long, placebo-controlled clinical trials of the Rottapharm brand of glucosamine sulfate. These studies both demonstrated a clear benefit for glucosamine treatment (Reginster et al., 2001; Pavelká et al., 2002). There was not only an improvement in symptoms but also an improvement in joint space narrowing on radiographs. This suggested that glucosamine, unlike pain relievers such as NSAIDs, can actually help prevent the destruction of cartilage that is the hallmark of osteoarthritis. On the other hand, several subsequent studies, independent of Rottapharm, but smaller and shorter, did not detect any benefit of glucosamine (Hughes et al., 2002; Cibere et al., 2004).
This situation led the National Institutes of Health to fund a large, multicenter clinical trial to test the effects of chondroitin sulfate, glucosamine, and the combination on painful osteoarthritis of the knee, compared to both placebo and celecoxib. The results of this 6-month trial found that patients taking glucosamine HCl, chondroitin sulfate, or a combination of the two had no statistically significant improvement in their symptoms compared to patients taking a placebo (Clegg et al., 2006). The group of patients who took celecoxib did have a statistically significant improvement in their symptoms. These results suggest that glucosamine and chondroitin do not effectively relieve pain in osteoarthritis patients.
Although the study found no effect for the supplements overall, a secondary analysis of a subgroup of patients suggested that the supplements might help people with pain classified as moderate to severe (see testing hypotheses suggested by the data). In an accompanying editorial, Dr. Marc Hochberg also noted that "It is disappointing that the GAIT investigators did not use glucosamine sulfate ... since the results would then have provided important information that might have explained in part the heterogeneity in the studies reviewed by Towheed and colleagues[PMID 15846645]" (Hochberg et al., 2006). But this concern is not shared by pharmacologists at the PDR who state, "The counter anion of the glucosamine salt (i.e. chloride or sulfate) is unlikely to play any role in the action or pharmacokinetics of glucosamine"[6]. Thus the question of glucosamine's efficacy will not be resolved without further updates or trials.
MSM Description
Methyl-sulphyl-methane (MSM) is an organic sulphur compound which is a metabolite of dimethyl sulphoxide. MSM is a naturally occurring substance that is found in both plants and animals, and is a potent dietary source of suphur, which is needed in amino acid and protein synthesis as well as in the formation of connective tissue. Sulphur is also required by the body in keratin formation, production of immunoglobulin as part of the immune system, and catalysing the metabolic reactions that change food into energy.
Uses & Benefits of MSM
Animal studies on cartilage in degenerative arthritis have been found to have a substantially lower (approximately one third) sulphur concentration in arthritic cartilage, when compared to normal cartilage. There is much anecdotal evidence provided by both health professionals and individuals of a reduction in levels of arthritic pain from taking a diet high in sulphur in the form of MSM. To date, there is only preliminary work that has been carried out in people that validates this, and more research is currently underway to determine exactly what role MSM plays and its dietary importance in the maintenance of healthy joints and cartilage.
MSM, Methyl Sulphonyl Methane is a naturally occurring sulfur compound. It is a natural source of sulfur. Sulfur exists in every cell of our body and is found in animal protein food such as fish, meat, milk and also in fruit and vegetables.
Sulfur is an element found in all living organisms and the fourth largest mineral found in the human body. It is found in every cell of our body. Approx. half of the total body sulfur is concentrated in the muscles, bones and skin. Sulfur is a component of protein Keratin found in nails, hair and skin. Sulfur is essential for the production of collagen which is a primary constituent of cartilage and connective tissue. It is needed for the synthesis of connective tissue, enzymes and immunoglobulin. It is also needed to form serum proteins. It is important for the sulfur amino acids like methionine, cysteine and taurine. Sulfur has a role in liver to secrete bile. It acts as a scavenger and takes out free radicals. Sulfur is a significant component of Insulin, the protein hormone secreted by the pancreas, that is essential to the metabolism of carbohydrates.
